| 项目编号 |
PRJCA030028 |
| 项目标题 |
Dexmedetomidine Decreases Cerebral Hyperperfusion Incidence Following Carotid Stenting: A Double-blind Randomized Controlled Trial |
| 涉及领域 |
Medical |
| 数据类型 |
metabonomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
The matrix was imported in R to carry out Principle Component Analysis (PCA) to observe the overall distribution among the samples and the stability of the whole analysis process. Orthogonal Partial Least-Squares-Discriminant Analysis (OPLS-DA) and Partial Least-Squares-Discriminant Analysis (PLS-DA) were utilized to distinguish the metabolites that differ between groups. To prevent overfitting, 7-fold cross-validation and 200 Response Permutation Testing (RPT) were used to evaluate the quality of the model. Variable Importance of Projection (VIP) values obtained from the OPLS-DA model were used to rank the overall contribution of each variable to group discrimination. A two-tailed Students T-test was further used to verify whether the metabolites of difference between groups were significant.Differential metabolites were selected with VIP values greater than 1.0 and p-values less than 0.05. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-09-10 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Dexmedetomidine decreases cerebral hyperperfusion incidence following carotid stenting: A double-blind, randomized controlled trial
|
Med
|
10.1016/j.medj.2024.09.012
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China
|
|
No.82271288
|
|
| Henan Provincial Science and Technology Research Project
|
|
No.242300421192
|
|
| Henan Provincial Science and Technology Research Project
|
|
JQRC2023004
|
|
|
|
| 提交者 |
Enqiang
Chang (changenqiang@zzu.edu.cn)
|
| 提交单位 |
People's Hospital of Zhengzhou |
| 提交日期 |
2024-09-10 |
