| Accession |
PRJCA030028 |
| Title |
Dexmedetomidine Decreases Cerebral Hyperperfusion Incidence Following Carotid Stenting: A Double-blind Randomized Controlled Trial |
| Relevance |
Medical |
| Data types |
metabonomics
|
| Organisms |
Homo sapiens
|
| Description |
The matrix was imported in R to carry out Principle Component Analysis (PCA) to observe the overall distribution among the samples and the stability of the whole analysis process. Orthogonal Partial Least-Squares-Discriminant Analysis (OPLS-DA) and Partial Least-Squares-Discriminant Analysis (PLS-DA) were utilized to distinguish the metabolites that differ between groups. To prevent overfitting, 7-fold cross-validation and 200 Response Permutation Testing (RPT) were used to evaluate the quality of the model. Variable Importance of Projection (VIP) values obtained from the OPLS-DA model were used to rank the overall contribution of each variable to group discrimination. A two-tailed Students T-test was further used to verify whether the metabolites of difference between groups were significant.Differential metabolites were selected with VIP values greater than 1.0 and p-values less than 0.05. |
| Sample scope |
Monoisolate |
| Release date |
2024-09-10 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China
|
|
No.82271288
|
|
| Henan Provincial Science and Technology Research Project
|
|
No.242300421192
|
|
| Henan Provincial Science and Technology Research Project
|
|
JQRC2023004
|
|
|
|
| Submitter |
Enqiang
Chang (changenqiang@zzu.edu.cn)
|
| Organization |
People's Hospital of Zhengzhou |
| Submission date |
2024-09-10 |
