| 项目编号 | PRJCA030049 | ||||||||||
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| 项目标题 | Chinese Immune Multi-Omics Atlas | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Whole genome sequencing
Epigenomics Transcriptome or Gene expression Variation Single cell sequencing |
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| 描述信息 | Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetics through multi-omics analysis of > 10 million immune cells from 428 adults. CIMA established an enhancer-driven gene regulatory network comprising 237 robust regulons, identified 9,600 cis-expression quantitative trait loci (eQTLs) and 52,361 chromatin accessibility QTLs (caQTLs) at cell-type resolution, and revealed pleiotropic associations among immune-related disease risk loci, eQTLs, and caQTLs. Furthermore, the novel CIMA-CLM model predicts chromatin accessibility and noncoding variant impacts from chromatin sequences and gene expression. CIMA provides a comprehensive reference for immune-related disease research. | ||||||||||
| 样品范围 | Multiisolate | ||||||||||
| 发布日期 | 2026-01-09 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | Chuanyu Liu (liuchuanyu@genomics.cn) | ||||||||||
| 提交单位 | BGI | ||||||||||
| 提交日期 | 2024-09-10 |
| 资源名称 | 描述 |
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| BioSample (822) show | - |