| 项目编号 |
PRJCA030099 |
| 项目标题 |
A novel protein NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in renal tubular epithelial cells-4 |
| 涉及领域 |
Medical |
| 数据类型 |
metabonomics
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Lipid extraction from H/R-induced control and CircNSD1-overexpressing cells was performed using a standardized protocol. Quality control (QC) samples were prepared by pooling equal volumes of extracts from all samples, ensuring that the volume of each QC sample was equivalent to that of the individual samples. Subsequently, the samples were subjected to separation using a Nexera UPLC system (Shimadzu) and analyzed via a Q Exactive mass spectrometer (Thermo Scientific). The LC/MS detection was carried out at Lumingbio Company. To identify differential lipid metabolites, a supervised multiple regression orthogonal partial least squares discriminant analysis (OPLS-DA) model was applied. To mitigate the risk of over-fitting, permutation testing was conducted with 200 iterations. The resulting data were deposited into a relevant database for further analysis and reference. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-09-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40663488
|
NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in tubular epithelial cells
|
JCI Insight
|
10.1172/jci.insight.189130
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| the National Natural Science Foundation
|
|
82300820
|
|
| the China Postdoctoral Science Foundation
|
|
2023T160001
|
|
| the China Postdoctoral Science Foundation
|
|
2022M710179
|
|
|
|
| 提交者 |
Li
Gao (18056052029@163.com)
|
| 提交单位 |
The First Affiliated Hospital of Anhui Medical University |
| 提交日期 |
2024-09-12 |
