Accession

PRJCA030120

Title

Comprehensive Evolutionary Characterization of Somatic Mutations in Chinese Lung Adenocarcinoma

Relevance

Medical

Data types

Whole genome sequencing

Organisms

Homo sapiens

Description

To investigate genomic driver events in both the coding and non-coding regions, we performed a whole-genome sequencing of 251 LUADs of Chinese ancestry. In addition to previously reported LUAD driver genes, we identified a number of novel, potentially oncogenic genes and non-coding regulatory elements. More importantly, by inferring the timing of these somatic events, we observed varied genomic patterns across different epochs during tumor evolution.

Sample scope

Multiisolate

Release date

2024-09-12

Grants

Agency	program	Grant ID	Grant title
National Natural Science Foundation of China (NSFC)		82388102
National Natural Science Foundation of China (NSFC)		81922061
National Natural Science Foundation of China (NSFC)		82072579
National Natural Science Foundation of China (NSFC)		82103926
National Natural Science Foundation of China (NSFC)		32370628
National Natural Science Foundation of China (NSFC)		92159302
National Natural Science Foundation of China (NSFC)		32170592
Outstanding Youth Foundation of Jiangsu Province		BK20220050
Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer, Chinese Academy of Medical Sciences		2019RU038
Natural Science Foundation of Jiangsu Province		BK20210534

Submitter

Na Qin (naqin@njmu.edu.cn)

Organization

Nanjing Medical University

Submission date

2024-09-12

Project Data

Resource name	Description