| 项目编号 |
PRJCA030120 |
| 项目标题 |
Comprehensive Evolutionary Characterization of Somatic Mutations in Chinese Lung Adenocarcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Whole genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
To investigate genomic driver events in both the coding and non-coding regions, we performed a whole-genome sequencing of 251 LUADs of Chinese ancestry. In addition to previously reported LUAD driver genes, we identified a number of novel, potentially oncogenic genes and non-coding regulatory elements. More importantly, by inferring the timing of these somatic events, we observed varied genomic patterns across different epochs during tumor evolution. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-09-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients
|
Cancer Research
|
10.1158/0008-5472.CAN-24-1799
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82388102
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81922061
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82072579
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82103926
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32370628
|
|
| National Natural Science Foundation of China (NSFC)
|
|
92159302
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32170592
|
|
| Outstanding Youth Foundation of Jiangsu Province
|
|
BK20220050
|
|
| Research Unit of Prospective Cohort of Cardiovascular Diseases and Cancer, Chinese Academy of Medical Sciences
|
|
2019RU038
|
|
| Natural Science Foundation of Jiangsu Province
|
|
BK20210534
|
|
|
|
| 提交者 |
Na
Qin (naqin@njmu.edu.cn)
|
| 提交单位 |
Nanjing Medical University |
| 提交日期 |
2024-09-12 |
