| 项目编号 |
PRJCA030133 |
| 项目标题 |
Untarget metabolites for analysis of crizotinib-induced hepatotoxicity |
| 涉及领域 |
Medical |
| 数据类型 |
metabolomics
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Crizotinib's hepatotoxicity was reported to associate with global metabolism abnormality and this study aims to clarify crizotinib-induced hepatotoxicity in order to better use of crizotinib in clinic. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-02-01 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39836491
|
Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity
|
Advanced Science
|
10.1002/advs.202414923
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82173893
|
Blockade of MET autophagic degradation in cardiomyocytes by crizotinib induces cardiotoxicity
|
|
|
| 提交者 |
xiangliang
huang (huangxiangliang@zju.edu.cn)
|
| 提交单位 |
Zhejiang University |
| 提交日期 |
2024-09-12 |
