| Accession |
PRJCA030245 |
| Title |
Cortical arealization of interneurons in developing human and macaque brains |
| Relevance |
Evolution |
| Data types |
Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
|
| Organisms |
Mus musculus
|
| Description |
Cortical interneurons generated from ganglionic eminence via a long-distance journey of tangential migration display evident cellular and molecular differences across brain regions, which seeds the heterogeneous cortical circuitry in primates. However, whether such regional specifications in interneurons are intrinsically encoded or gained through interactions with the local milieu remains elusive. Here, we recruit over 700,000 interneurons from cerebral cortex and subcortex including ganglionic eminence within the developing human and macaque species. The spatial and temporal characteristics of cortical interneurons are described through analysis, providing a new proxy for understanding the relationship between cell diversity and functional progression. |
| Sample scope |
Single cell |
| Release date |
2024-11-29 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
32270715
|
|
|
|
| Submitter |
Mingfeng
Li (mingfengli@hust.edu.cn)
|
| Organization |
Huazhong University of Science and Technology |
| Submission date |
2024-09-17 |
