| 项目编号 |
PRJCA030503 |
| 项目标题 |
Lipidomics analysis of gastric cancer |
| 涉及领域 |
Medical |
| 数据类型 |
lipidome
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
We aimed to establish a serum lipid metabolic signature (SLMS) for GC diagnosis and gastric cancer prognostic subtypes (GCPS) for prognosis prediction of GC through lipid metabolic fingerprint and machine learning. This study incorporated serum lipidomics data from 944 participants, including 440 GC patients, 71 patients with gastric precancerous lesions (PLs) and 433 healthy donors (HDs). Discovery and validation phases of SLMS and GCPS were conducted through linear discriminant analysis (LDA) and clustering analysis on serum lipid metabolic profile obtained by ultra-performance liquid chromatography-MS (UPLC-MS). Additionally, multi-omics analysis was performed to further interpret the lipid metabolism disturbance in GC. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-09-25 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Diagnosis and prognosis prediction of gastric cancer by high-performance serum lipidome fingerprints
|
EMBO Molecular Medicine
|
10.1038/s44321-024-00169-0
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2022YFA1105300
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82341010
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82273241
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81972625
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32201217
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2023B1515040030
|
|
| Liaoning Revitalization Talents Program
|
|
XLYC2002035
|
|
| Sanming Project of Medicine in Shenzhen
|
|
SZSM202211017
|
|
| Young Talents Program of Sun Yat-sen University Cancer Center
|
|
YTP-SYSUCC-0019
|
|
|
|
| 提交者 |
HuaiQiang
Ju (juhq@sysucc.org.cn)
|
| 提交单位 |
State Key Laboratory of Oncology in South China/Collaborative Innovation Center for Cancer Medicine/Sun Yat-sen University Cancer Center |
| 提交日期 |
2024-09-25 |
