| 项目编号 |
PRJCA030639 |
| 项目标题 |
A metabonomics analysis of the effects of cryptotanshinone and arsenic trioxide on hepatocellular carcinoma. |
| 涉及领域 |
Model organism |
| 数据类型 |
Metabolomics
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Hepatocellular carcinoma represents one of the most significant global health burdens in terms of morbidity and mortality. In recent years, there has been a growing body of evidence indicating that combination therapy has emerged as a promising strategic approach for the treatment of advanced hepatocellular carcinoma (HCC). In light of these findings, we put forth a potential therapeutic combination for HCC: cryptotanshinone in conjunction with arsenic trioxide, designated as ACCS. The metabolic landscape within the tumor microenvironment (TME) is intricate, with tumor cells exhibiting distinctive metabolic phenotypes to sustain the energy demands of their rapid proliferation. Energy metabolomics was employed to investigate the impact of ACCS intervention on metabolite alterations in normoxic and hypoxic environments. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-10-22 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39519335
|
Elucidation of the Role of SHMT2 in L-Serine Homeostasis in Hypoxic Hepa1-6 Cells
|
International Journal of Molecular Sciences
|
10.3390/ijms252111786
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82030119
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82204950
|
|
|
|
| 提交者 |
Mengting
Wu (wmt_0917@163.com)
|
| 提交单位 |
Zhejiang Chinese Medical University |
| 提交日期 |
2024-09-27 |
