1. Home
  2. Browse
  3. PRJCA030749
项目编号 PRJCA030749
项目标题 Precise positioning and fate determination of embryonic cardiac progenitors
涉及领域 Medical
数据类型 Transcriptome or Gene expression
Raw sequence reads
Single cell sequencing
物种名称 Mus musculus
Danio rerio
Rattus norvegicus
Homo sapiens
描述信息 Cardiovascular diseases have emerged as a significant public health challenge in China. Congenital heart disease (CHD), the most prevalent birth defect in the country, accounts for approximately 28% of all congenital anomalies and can result severe symptoms such as hypoxia, shock, and even neonatal mortality. The underlying cause is often abnormal heart development during embryogenesis. Despite advancements in identifying regulatory factors and subclasses of cardiac progenitor cells, our understanding of how these cells differentiate from the mesoderm and the mechanisms governing their lineage progression and fate determination remains incomplete. This project endeavors to precisely locate and trace early embryonic cardiac progenitor cells, unveiling the external (morphogen gradients) and internal (gene transcription and epigenetic regulatory networks) regulatory mechanisms. By elucidating the mechanisms of cardiac progenitor cell formation and fate determination, this project aims to contribute to the prevention and treatment of heart development-related diseases. The project encompasses four research topics: 1. Precise Localization and Epigenetic Analysis of Cardiac Progenitor Cells: To pinpoint the location of cardiac progenitor cells and analyze their epigenetic signatures. 2. The Role and Mechanism of Morphogens in the Generation of Cardiac Progenitor Cells: To investigate the functions and mechanisms of morphogens in initiating the formation of cardiac progenitor cells. 3. Regulatory Mechanisms of Epigenetic Regulatory Networks in the Specification of Cardiac Progenitor Cells: To explore how epigenetic regulatory networks control the differentiation of cardiac progenitor cells.4. Intervention Mechanisms in the Generation and Fate Determination of Human Cardiac Progenitor Cells: To study the mechanisms that can be intervened to influence the generation and fate determination of human cardiac progenitor cells.
样品范围 Multiisolate
发布日期 2024-10-09
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
Ministry of Science and Technology of the People's Republic of China (MOST) National Key Technologies R&D Program 2018YFA0800100 Precise positioning and fate determination of embryonic cardiac progenitors
提交者 chengqi lin (cqlin@seu.edu.cn)
提交单位 Southeast University
提交日期 2024-09-14

项目包含数据信息

资源名称 描述
BioSample (857)  show -
GSA (5) -
CRA019561 HEY2 (GRIDLOCK) regulates mitochondrial oxidative respiration to maintain cardiac homeostasis
CRA019854 Molecular architecture of lineage specification and tissue organization in early mouse embryo
CRA019631 Epigenomic landscape of the mouse gastrula
CRA019616 Total RNA profiles of mouse early embryonic samples were generated by deep sequencing.
CRA019483 RNA-Seq of mESC-E14