| 项目编号 | PRJCA030875 | ||||||||||
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| 项目标题 | Systemic Geroprotective Effects of Seno-Resistant Human Mesenchymal Progenitor Cells in Macaques | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 数据类型 |
Whole genome sequencing
Transcriptome or Gene expression Single cell sequencing Multiple omics data |
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| 物种名称 |
Mus musculus
Macaca fascicularis Homo sapiens Mus |
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| 描述信息 | Aging is characterized by a decline in stem cell function, and the potential for replenishing these cells to combat aging is not well understood. Our study addresses this gap by creating seno-resistant human mesenchymal progenitor cells (SRCs), which are genetically enhanced to promote cellular resilience. In a 44-week study, we administered SRCs intravenously to aged macaques and observed reductions in signs of aging across 22 tissue types. Improvements included decreased disorganization and dysfunction in tissues, reduced cellular senescence, and lower molecular aging markers, with no observed negative side effects. Notably, SRC therapy improved brain structure and cognitive performance while slowing the deterioration of the reproductive system. | ||||||||||
| 样品范围 | Multiisolate | ||||||||||
| 发布日期 | 2025-06-06 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | juan zi xin (xinzijuan@ioz.ac.cn) | ||||||||||
| 提交单位 | Institute of Zoology, Chinese Academy of Sciences | ||||||||||
| 提交日期 | 2024-10-07 |