| 项目编号 | PRJCA031037 | ||||||||||
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| 项目标题 | αTIGIT-IL2 promotes tumor-infiltrating regulatory T cell fragility resulting in tumor regression | ||||||||||
| 涉及领域 | Medical | ||||||||||
| 先导项目 |
IDP: The Immunity Deciphering Project |
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| 数据类型 | Single cell sequencing | ||||||||||
| 物种名称 | Mus musculus | ||||||||||
| 描述信息 | We designed an immunocytokine fused by IL-2 and an anti-TIGIT monoclonal antibody, named αTIGIT-IL2, targeting Treg cells and promoting their fragility in tumor area. C57BL/6 mice (n = 5) were inoculated with 5E5 MC38 cells. Tumor-bearing mice were intraperitoneally treated with PBS or 10 μg αTIGIT-IL2 on days 7, 10, and 13. Mice were harvested and TILs were isolated for scRNA-seq 1 day after the last treatment. | ||||||||||
| 样品范围 | Single cell | ||||||||||
| 发布日期 | 2025-08-11 | ||||||||||
| 出版信息 |
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| 项目资金来源 |
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| 提交者 | cris tianci wang (wtcnwafu@163.com) | ||||||||||
| 提交单位 | University of Science and Technology of China | ||||||||||
| 提交日期 | 2024-10-11 |