| Accession |
PRJCA031157 |
| Title |
Inosine monophosphate overcomes the coexisting resistance of mcr-1 and blaNDM-1 in Escherichia coli |
| Relevance |
Agricultural |
| Data types |
Transcriptome or Gene expression
Metabolome
|
| Organisms |
Escherichia coli
|
| Description |
The rise of antibiotic-resistant bacteria, particularly those harboring mcr-1 and blaNDM-1, threatens public health by reducing the efficacy of colistin and carbapenems. Recently, the co-spread of mcr-1 and blaNDM-1 has been reported, and the emergence of dual-resistant Enterobacteriaceae severely exacerbates antimicrobial resistance. This study used non-targeted metabolomics to investigate the impact of mcr-1 and blaNDM-1 expression on bacterial metabolism. Based on the metabolic alteration, we identified a novel bactericidal metabolite and further explored its potential antibacterial mechanisms. |
| Sample scope |
Monoisolate |
| Release date |
2024-10-15 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Key Research and Development Program of China
|
|
2023YFD1800800
|
|
|
|
| Submitter |
Liang
Zhao (1343230471@qq.com)
|
| Organization |
China Agricultural University |
| Submission date |
2024-10-14 |
