| 项目编号 |
PRJCA031278 |
| 项目标题 |
A transcriptome analysis was conducted to investigate the potential of cryptotanshinone in combination with arsenic trioxide as a treatment for hepatocellular carcinoma |
| 涉及领域 |
Model organism |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Hepatocellular carcinoma represents one of the most significant global health burdens in terms of morbidity and mortality. In recent years, mounting evidence has indicated that combination therapy has emerged as a promising strategic approach for the treatment of advanced hepatocellular carcinoma. Based on this evidence, we propose a potential therapeutic combination for hepatocellular carcinoma, namely cryptotanshinone in combination with arsenic trioxide, which we have designated as ACCS. To elucidate the intrinsic mechanism by which ACCS exerts its anti-hepatocellular carcinoma effects, we performed transcriptome sequencing of Hepa1-6 cells after ACCS intervention in normoxic and hypoxic environments. This approach allowed us to identify the pathways and key targets associated with the observed effects. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-10-17 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39519335
|
Elucidation of the Role of SHMT2 in L-Serine Homeostasis in Hypoxic Hepa1-6 Cells
|
International Journal of Molecular Sciences
|
10.3390/ijms252111786
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82030119
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82204950
|
|
|
|
| 提交者 |
Mengting
Wu (wmt_0917@163.com)
|
| 提交单位 |
Zhejiang Chinese Medical University |
| 提交日期 |
2024-10-17 |
