| 项目编号 |
PRJCA031327 |
| 项目标题 |
A Global Epidemic Serotype 14 Streptococcus pneumoniae Switching to non-Vaccine Types |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Streptococcus pneumoniae
|
| 描述信息 |
In this study, we collected 166 S. pneumoniae clinical isolates and identified multidrug-resistant NVT S. pneumoniae isolates that recently emerged within the epidemic CC876 complex. We defined the strain as 15B/ST 4749 which might be generated through a serotype-switch event from serotype 14/ST4749. Mapping the genomic recombination sites within the serotype 15B/ST 4749 progeny revea4led a donated fragment encompassing cps, pbp1a, and additional key factors, including the DNA uptake-related gene comC. More importantly, ST4749 strains belonged to the epidemic CC876 complex, the novel NVT strain has the potential to be a global pandemic strain. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-10-18 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40162764
|
A global epidemic serotype 14 Streptococcus pneumoniae switching to non-vaccine types
|
Microbiology Spectrum
|
10.1128/spectrum.03151-24
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82272339
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2021YFF0703805
|
|
| the Outstanding Young Talents Program of Capital Medical University
|
|
A2206
|
|
|
|
| 提交者 |
Chen
Chen (chenchen1@ccmu.edu.cn)
|
| 提交单位 |
Beijing Shijitan Hospital, Capital Medical University |
| 提交日期 |
2024-10-15 |
