| 项目编号 |
PRJCA031548 |
| 项目标题 |
VCAN in the extracellular matrix drives glioma recurrence by enhancing cell proliferation and migration |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
In this study, we first identified the ECM and the Versican (VCAN), a key ECM protein, as critical contributors to glioma recurrence through a comprehensive analysis of transcriptomic data comparing recurrent and primary gliomas. Using single-cell sequencing, we revealed heterogeneous distribution patterns and extensive intercellular communication among ECM components. External sequencing and immunohistochemical (IHC) staining further validated that VCAN is significantly upregulated in recurrent gliomas and is associated with poor patient outcomes. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-11-30 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39554845
|
VCAN in the extracellular matrix drives glioma recurrence by enhancing cell proliferation and migration
|
Frontiers in Neuroscience
|
10.3389/fnins.2024.1501906
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82173090
|
|
|
|
| 提交者 |
Ruolun
Wei (rlwei@stanford.edu)
|
| 提交单位 |
Stanford University |
| 提交日期 |
2024-10-23 |
