| 项目编号 |
PRJCA031709 |
| 项目标题 |
The Research of Knock out of High-Risk Genes for Depression |
| 涉及领域 |
Model organism |
| 数据类型 |
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
According to data from the World Health Organization (WHO), the global prevalence of depression is estimated to be 3.8%, including 5% of adults (4% among men and 6% among women), and 5.7% of adults aged 60 and above. Approximately 280 million people worldwide are affected by depression. With the extensive research on WGAS technology, numerous loci and genes highly associated with depression have been identified. However, there is a scarcity of research on how these high-risk genes influence the phenotype of depression, particularly large-scale validation studies. In this project, we utilize perturb-seq technology to conduct perturbation studies on high-risk genes associated with depression, investigating how the knockout of each high-risk gene at the single-cell transcriptome level induces related phenotypes. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-11-26 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
STI2030-Major Projects of China
|
2021ZD0200900
|
|
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFC3400100
|
|
| The Science and Technology Commission of Shanghai Municipality (STCSM)
|
the Shanghai 2023 Special Biopharmaceutical Science and Technology Support Projects
|
23S41900300
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
T2394534
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82001202
|
|
| The Science and Technology Commission of Shanghai Municipality (STCSM)
|
Shanghai Pujiang Talent Program
|
2020PJD006
|
|
|
|
| 提交者 |
Zhengzheng
Xu (zzxu@ion.ac.cn)
|
| 提交单位 |
institute of neuronscience, CAS |
| 提交日期 |
2024-10-28 |
