| Accession | PRJCA031714 | ||||||||
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| Title | Development and preclinical study of primate models of complex developmental and metabolic diseases | ||||||||
| Relevance | Medical | ||||||||
| Data types |
Phenotype or Genotype
Transcriptome or Gene expression Genome sequencing Single cell sequencing |
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| Organisms |
Mus musculus
feces metagenome Myomorpha Macaca fascicularis Macaca Macaca mulatta Mus Homo mixed sample |
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| Description | This project aims at the major needs of the "Development Programming and Metabolic Regulation" key project application guide 2018 "Creation of Primate models of Developmental and metabolic Diseases" to carry out the following research: 1) Establish targeted gene editing technology with independent intellectual property rights, and develop new gene editing methods that can be used in clinical treatment; 2) To create developmental degenerative diseases (Duchenne muscular dystrophy, premature aging), neurodegenerative developmental diseases (Alzheimer's disease, Parkinson's disease), brain developmental cognitive diseases (Fragile X) that can objectively reflect the characteristics of human diseases Primate models of syndromes, angelic syndrome, autism), metabolic diseases (diabetes, inherited metabolic defects of the liver, thalassemia, gout) and cardiovascular and metabolic diseases (metabolic syndrome, atherosclerosis and coronary heart disease, etc.); 3) Establish a new technology for the study of disease mechanism, and analyze the pathogenesis by combining multi-omics and early embryonic development research methods; 4) Develop new methods of gene editing tool delivery that can be used for clinical treatment, and study the safety and effectiveness of multiple repair methods of gene therapy based on primate disease models; 5) Establish geneticially-modified primate resource database and platform, including disease model monkey population, histometer bank, physiological and pathological database, development map, gene expression profile, proteomics profile, intestinal flora profile, metabolomics profile, etc., to provide shared resources and services for disease research, drug development and clinical transformation. | ||||||||
| Sample scope | Multispecies | ||||||||
| Release date | 2024-11-08 | ||||||||
| Grants |
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| Submitter | Wei Si (wangd@lpbr.cn) | ||||||||
| Organization | Kunming University of Science and Technology | ||||||||
| Submission date | 2024-10-28 |
| Resource name | Description |
|---|---|
| BioSample (32) show | - |