| 项目编号 |
PRJCA031722 |
| 项目标题 |
Fatty Acid Synthase (FASN) Sustains Leukemogenesis by Inhibiting Progranulin-Mediated Lysosomal and Inflammatory Signaling |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
Proteomics, Lipidomics
|
| 物种名称 |
|
| 描述信息 |
In this project, we demonstrated that FASN is essential for leukemogenesis. To investigate the role of FASN in leukemia progression, we established MOLM-13 cells with FASN knockdown. The cells were collected after selection with 1μg/mL puromycin for two days. Additionally, we treated MOLM-13 cells with a FASN inhibitor, MS-C19 (5μM), for 48 hours. The samples were collected for RNA sequencing, label-free quantitative proteomics, and lipidomics analysis. By performing multi-omics analysis on FASN-depleted and control MOLM-13 cells, as well as MS-C19 treated and untreated cells, we demonstrated that both MS-C19 treatment and FASN deficiency triggered the activation of lysosomal and inflammatory gene expression. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2026-01-07 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82170160
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32000604
|
|
| Provincial Natural Science Foundation of Hunan
|
|
2022JJ20021
|
|
| Hunan University
|
|
531119200159
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82204462
|
|
| Provincial Natural Science Foundation of Hunan
|
|
2023JJ40200
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82074508
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82173688
|
|
| Global Research Award from the American Society of Hematology
|
|
NA
|
|
|
|
| 提交者 |
Yang
Mei (yanmei@hnu.edu.cn)
|
| 提交单位 |
Hunan University |
| 提交日期 |
2024-10-28 |
