| Accession |
PRJCA031863 |
| Title |
SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
MS
|
| Organisms |
Mus musculus
Homo sapiens
|
| Description |
Our findings demonstrate that reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine-tuning the transcriptional activity of HEY1. Specifically, SUMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA-binding capability in endothelial cells. |
| Sample scope |
Monoisolate |
| Release date |
2024-11-02 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 38166414
|
|
|
|
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
|
2018YFA0800500
|
|
|
|
| Submitter |
jinying
li (jinyingli@zju.edu.cn)
|
| Organization |
Zhejiang University |
| Submission date |
2024-10-29 |
