| Accession |
PRJCA032120 |
| Title |
Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats. |
| Relevance |
Medical |
| Data types |
Transcriptome or Gene expression
|
| Organisms |
Rattus norvegicus
|
| Description |
This study investigates the potential of short-chain fatty acids (SCFAs) as an intervention for alcohol use disorder (AUD), a major public health issue with limited therapeutic options. Using alcohol-preferring rats, intragastric administration of SCFAs significantly reduced alcohol consumption and mitigated alcohol-induced intestinal, hepatic, and neuroinflammation. These findings highlight the relevance of SCFAs, particularly butyrate, as a safe, cost-effective strategy for addressing AUD. |
| Sample scope |
Multiisolate |
| Release date |
2024-11-30 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| ANID
|
FONDECYT
|
1240162
|
|
|
|
| Submitter |
Ignacio
Valenzuela (ignmartinez@udec.cl)
|
| Organization |
Universidad de Concepcion |
| Submission date |
2024-11-08 |
