| Accession |
PRJCA032297 |
| Title |
T-cell receptor and B-cell Receptor Repertoires Profiling in Pleural Tuberculosis |
| Relevance |
Medical |
| Data types |
Raw sequence reads
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
Tuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB). An important clinical feature of PLTB is that the lymphocytes associated with TB will accumulate in the pleural fluid. The adaptive immune repertoires play important roles in Mycobacterium tuberculosis(Mtb) .In this study, 10 PLTB patients were enrolled, and their Peripheral Blood Mononuclear Cells(PBMCs) and Pleural Effusion Mononuclear Cells(PEMCs) were collected. After T cells were purified from PBMCs and PEMCs, high-throughput immunosequencing of the TCRβ chain(TRB), TCRγ chain(TRG), and B cell receptor(BCR) immunoglobulin heavy chain (IGH) were conducted on these samples. |
| Sample scope |
Single cell |
| Release date |
2024-11-13 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
|
32070937
|
|
| China Postdoctoral Science Foundation
|
|
2017M620052
|
|
|
|
| Submitter |
Hao
Li (lihaocau@cau.edu.cn)
|
| Organization |
China Agricultural University |
| Submission date |
2024-11-13 |
