| 项目编号 |
PRJCA032297 |
| 项目标题 |
T-cell receptor and B-cell Receptor Repertoires Profiling in Pleural Tuberculosis |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Tuberculosis (TB) is a leading cause of death worldwide from a single infectious agent. In China the most common extra-pulmonary TB (EPTB) is pleural tuberculosis (PLTB). An important clinical feature of PLTB is that the lymphocytes associated with TB will accumulate in the pleural fluid. The adaptive immune repertoires play important roles in Mycobacterium tuberculosis(Mtb) .In this study, 10 PLTB patients were enrolled, and their Peripheral Blood Mononuclear Cells(PBMCs) and Pleural Effusion Mononuclear Cells(PEMCs) were collected. After T cells were purified from PBMCs and PEMCs, high-throughput immunosequencing of the TCRβ chain(TRB), TCRγ chain(TRG), and B cell receptor(BCR) immunoglobulin heavy chain (IGH) were conducted on these samples. |
| 样品范围 |
Single cell |
| 发布日期 |
2024-11-13 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39664375
|
T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis
|
Frontiers in Immunology
|
10.3389/fimmu.2024.1473486
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32070937
|
|
| China Postdoctoral Science Foundation
|
|
2017M620052
|
|
|
|
| 提交者 |
Hao
Li (lihaocau@cau.edu.cn)
|
| 提交单位 |
China Agricultural University |
| 提交日期 |
2024-11-13 |
