| 项目编号 |
PRJCA032370 |
| 项目标题 |
Transcriptome sequencing of DNA demethylation in Meibomian Gland Carcinoma |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Unveiling the mechanisms of DNA demethylation in meibomian gland carcinoma through transcriptome sequencing offers a profound understanding of the specific processes involved, including the identification of genes or regions undergoing demethylation and their subsequent impact on gene expression. This approach also facilitates the identification of key genes, where demethylation events may activate oncogenes or inhibit tumor suppressor genes, providing crucial targets for gene therapy or targeted therapy. Moreover, by monitoring changes in DNA demethylation, we gain insights into the progression of meibomian gland carcinoma and the biological characteristics at various stages, aiding in the understanding of the disease. Based on these findings, therapeutic strategies targeting specific demethylation events or related genes can be devised, such as pharmacological intervention to reverse demethylation or gene editing technology to repair damaged genes. Additionally, the degree or pattern of DNA demethylation may serve as a prognostic indicator, enabling the establishment of prognosis assessment models through transcriptome sequencing to better predict patient outcomes and survival durations. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-05-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
E2F2 (E2F transcription factor 2) as a potential therapeutic target in meibomian gland carcinoma: evidence from functional and epigenetic studies
|
BMC Cancer
|
10.1186/s12885-025-13833-6
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Tianjin Health Science and Technology Project
|
|
TJWJ2022MS012
|
|
|
|
| 提交者 |
Wei
Wang (1109418072@qq.com)
|
| 提交单位 |
Tianjin Medical University Eye Hospital |
| 提交日期 |
2024-11-14 |
