| 项目编号 |
PRJCA032848 |
| 项目标题 |
LEF-6 phosphorylation regulates the binding and trafficking of baculovirus late gene transcripts |
| 涉及领域 |
Agricultural |
| 数据类型 |
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Autographa californica nucleopolyhedrovirus
|
| 描述信息 |
AcMNPV is the most well studied baculovirus. As the viral vector in baculovirus expression vector system (BEVS), it has been widely used for the production of proteins in the basic research and pharmaceutical industry. In this study, we found that phosphorylated LEF-6 acted as a viral mRNA-binding and trafficking protein to accelerate the translation of viral late proteins and subsequently benefit baculovirus infection. The RNA-binding domain, nuclear localization signal motif and phosphorylation sites of LEF-6 were determined. Our findings can help to elucidate the roles of LEF-6 in baculovirus infectious cycle and improve the BEVS for protein production. |
| 样品范围 |
Synthetic |
| 发布日期 |
2024-11-27 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40787986
|
LEF-6 phosphorylation regulates the binding and trafficking of baculovirus late gene transcripts
|
Journal of Virology
|
10.1128/jvi.02100-24
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32270176
|
|
|
|
| 提交者 |
Chen
hong
ying (chenhy@nwsuaf.edu.cn)
|
| 提交单位 |
Northwest A&F University |
| 提交日期 |
2024-11-26 |
