| 项目编号 |
PRJCA032957 |
| 项目标题 |
MT-CO2 bridges Ras signaling to epigenetic regulation of GLS1 in promoting glutaminolysis for tumor cell survival upon glucose deprivation |
| 涉及领域 |
Medical |
| 数据类型 |
metabolome
|
| 物种名称 |
Homo sapiens
Homo
|
| 描述信息 |
In this study, we show that glucose deprivation leads to robust upregulation of the expression of MT-CO2, a mitochondrial genome-encoded protein essential in the complex IV of the respiratory chain, which bridges Ras signaling to epigenetic upregulation of JUN gene transcription via activation of the FAD-LSD1-H3K9me2 axis, consequently resulting in elevated GLS1 expression, glutaminolysis, and tumor cell survival. Inhibition of MT-CO2 by shRNA or berberine leads to inhibition of glutaminolysis and suppression of Ras-driven tumor growth. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2024-12-06 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39747079
|
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation
|
Nature Communications
|
10.1038/s41467-024-55768-9
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Ministry of Science and Technology of the People's Republic of China (MOST)
|
National Key Technologies R&D Program
|
2022YFA1103700
|
|
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82073248
|
|
| National Natural Science Foundation of China (NSFC)
|
Key Program
|
81830108
|
|
|
|
| 提交者 |
Yong
Yi (yy-yiyong@scu.edu.cn)
|
| 提交单位 |
Sichuan University |
| 提交日期 |
2024-11-28 |
