项目编号

PRJCA032992

项目标题

A hydrogel with adjustable therapeutic regimen for inactivating bacteria and reducing inflammation for wound healing

涉及领域

Medical

数据类型

Transcriptome or Gene expression
Single cell sequencing

物种名称

Mus

描述信息

Impaired wound healing is an obvious clinical concern that can be hindered by bacteria infection and inflammation. Although photodynamic therapy (PDT) has shown promise in anti-bacterial infection, the wound healing process is slow due to the lack of anti-inflammation function during treatment. To address this challenge, we have developed a photodynamic-based adjustable therapy to prevent infection and excessive inflammation, and accelerate wound healing. This strategy eliminates bacteria by generation sufficient reactive oxygen species (ROS) and nitric oxide (NO), then reduces inflammation by supplying oxygen (O2) and sustaining NO. Meanwhile, an adjustable therapeutic schedule based on the pH indicator was designed to conduct anti-bacterial and anti-inflammatory activities at the proper stage during wound healing treatment. Here, we demonstrate the potential of this therapy for enhanced anti-infection, and ameliorate wound inflammation, providing a supportive environment for skin and superficial skeletal muscle wound healing in mice, rabbits and pigs. Collectively, our strategy provides an approach to apply PDT with transformative potential for infected skin and subcutaneous tissue wound healing.

样品范围

Multiisolate

发布日期

2025-12-31

项目资金来源

机构	项目类型	授权项目ID
National Natural Science Foundation of China (NSFC)	General Program	32225046
National Natural Science Foundation of China (NSFC)	General Program	32372846
National Natural Science Foundation of China (NSFC)	General Program	32421005
National Natural Science Foundation of China (NSFC)	General Program	32341051
Biological Breeding-National Science and Technology Major Project	General Program	2023ZD0406805
National Key R & D Program of China	General Program	2023YFD1301302
Sichuan Science and Technology Program	General Program	2024NSFSC1166
Sichuan Science and Technology Program	General Program	2021ZDZX0008
Sichuan Science and Technology Program	General Program	2021YFYZ0009

提交者

Jiaman Zhang (zjm960521@hotmail.com)

提交单位

Sichuan Agricultural University

提交日期

2024-11-29

项目包含数据信息

资源名称	描述
BioSample (39) show	-
SAMC4420688	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420687	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420686	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420685	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420684	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420683	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420682	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420681	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420680	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420679	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420678	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420677	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420676	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420675	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420674	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420673	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420672	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420671	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420670	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420669	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420668	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420667	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420666	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420665	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420664	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420663	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420662	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420661	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420660	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420659	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420658	Bulk RNA-seq of mus musculus (C57BL/6J): 12 weeks male skin
SAMC4420657	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420656	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420655	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420654	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420653	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420652	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420651	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
SAMC4420650	snRNA-seq of mus musculus (BALB/c): 7 weeks male skeletal muscle
GSA (1)	-
CRA020848	A hydrogel-based sequential photodynamic therapy promotes wound healing by targeting wound infection and inflammation