| Accession |
PRJCA033090 |
| Title |
Lipidomic, Proteomic, and Acetylome Alterations in Obesity-related Osteoarthritic Mouse Cartilage |
| Relevance |
Medical |
| Data types |
Lipidomic, proteomic and acetylome
|
| Organisms |
Mus musculus
|
| Description |
Male mice aged 4 weeks were housed under controlled conditions and assigned to either a normal diet or a high-fat diet for 16 weeks to establish an obesity model. At 12 weeks, osteoarthritis was induced using the destabilization of the medial meniscus procedure under anesthesia, while sham-operated mice served as controls. Eight weeks post-surgery, tibial cartilage tissues were collected, ensuring surrounding tissues were removed under a microscope. Tissues from 3-5 mice per group were pooled, and flash-frozen for subsequent lipidomic, proteomic, and acetylome analyses. |
| Sample scope |
Multiisolate |
| Release date |
2025-04-07 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 40425566
|
Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation
|
Nature Communications
|
10.1038/s41467-025-60037-4
|
2025
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
Excellent Young Scientists Fund
|
82422044
|
|
|
|
| Submitter |
Shuying
Shen (shenshuying@zju.edu.cn)
|
| Organization |
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine |
| Submission date |
2024-12-02 |
