| 项目编号 |
PRJCA033310 |
| 项目标题 |
Modulation of glymphatic system by visual circuit activation alleviates Alzheimer's disease-associated memory impairment and apathy in mice |
| 涉及领域 |
Medical |
| 数据类型 |
Metabolome
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Alzheimer's disease (AD) features progressive amyloid deposition and cognitive decline. Forty hertz (Hz) light treatment has been shown to improve cognitive function, but its mechanisms and efficacy with concomitant AD therapies remain underexplored. This study examined the effects of 14-day low-intensity 40 Hz blue light exposure on cognitive functions and pathological changes of 5xFAD mice at different ages. The treatment prevented memory decline in 4-month-old 5xFAD mice and motivation loss in 14-month-old 5xFAD mice, together with restoration of glymphatic drainage and AQP4 polarity in memory-related regions. Importantly, the improvement required glymphatic drainage and activation of the vLGN/IGL-Re circuit. Furthermore, the combined use of 40 Hz blue light with anti-Aβ antibody significantly enhanced soluble Aβ clearance and cognition in 5xFAD mice. These findings provide new insights into the therapeutic mechanisms of 40 Hz blue light in mouse model of AD-related pathology, suggesting potential clinical benefits of light therapy alongside anti-Aβ antibody therapy. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2024-12-05 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's disease
|
Nature Communications
|
10.1038/s41467-024-55678-w
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
81972967
|
|
|
|
| 提交者 |
Xin
Cheng (xcheng505@gmail.com)
|
| 提交单位 |
Sun Yat-sen University |
| 提交日期 |
2024-12-05 |
