| 项目编号 |
PRJCA033432 |
| 项目标题 |
Exosomal miR-375-3p mediated lipid metabolism, ferritinophagy and CoQ-dependent pathyway contributes to the ferroptosis of keratinocyte in SJS/TEN |
| 涉及领域 |
Medical |
| 数据类型 |
Nontargeted lipidomics and oxylipins
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
SJS and toxic epidermal necrolysis (TEN) manifest life-threatening cutaneous adverse drug reactions characterized by keratinocyte death. Previous studies have indicated that apoptosis and necroptosis are implicated in SJS/TEN pathogeneses. However, other forms of cell death involved in this process remain unidentified. Ferroptosis, cell death driven by iron-dependent lipid peroxidation, has been implicated in various human diseases. In this study, the identification of ferroptosis and the potential effects of ferroptosis on SJS/TEN were investigated. We demonstrated that the skin lesions and plasma of SJS/TEN patients show increased levels of lipid peroxidation and iron. Plasma exosomes from SJS/TEN patients increased cellular oxidized polyunsaturated fatty acids (PUFA) and phospholipids phosphatidylethanolamine (PE), the key phospholipids that drive cells towards ferroptotic death. Above all, we concluded that ferritinophagy-mediated ferroptosis, lipid metabolism, and the FSP-CoQ-dependent pathway in ferroptosis are critical mechanisms contributing to SJS/TEN. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-02-01 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39897035
|
Exosomal miR-375-3p mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN
|
International Journal of Biological Sciences
|
10.7150/ijbs.98592
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Major Program
|
82373472
|
|
|
|
| 提交者 |
Chen
Zhang (535618242@qq.com)
|
| 提交单位 |
Xijing Hospital, Fourth Military Medical University |
| 提交日期 |
2024-12-09 |
