| 项目编号 |
PRJCA033456 |
| 项目标题 |
Metabolic Recoding of 5'-Methylthioadenosine- Mediated H3K79me1 Demethylation Antagonizes Cadmium-Induced Breast Cancer Progression by Maintaining Autophagic Flux |
| 涉及领域 |
Medical |
| 数据类型 |
metabonomics
|
| 物种名称 |
|
| 描述信息 |
For LC-MS analysis, a precooled methanol-water solution was utilized for the extraction of cellular metabolites, and the subsequent mass spectrometric information was acquired using a Nexera UPLC coupled to a Q Exactive high-resolution mass spectrometer. GC-MS analysis was conducted on a 7890B-5977A GC-MS system (Agilent Technologies, Santa Clara, CA, USA) equipped with a DB-5MS column, employing a temperature gradient and electron ionization (EI) for metabolite separation and detection. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2026-01-15 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40919610
|
5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux
|
Advanced Science
|
10.1002/advs.202500941
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China
|
|
82173473
|
|
| National Natural Science Foundation of China
|
|
82173468
|
|
|
|
| 提交者 |
Jingdian
li (lijingdian_tmmu@163.com)
|
| 提交单位 |
Department of Occupational Health (Key Laboratory of Electromagnetic Radiation Protection, Ministry of Education), Army Medical University (Third Military Medical University), Chongqing 400038, China. |
| 提交日期 |
2024-12-09 |
