项目编号

PRJCA033503

项目标题

Thiamine-Mediated S100A9 Regulation of AKT/AMPK-Dependent Mitochondrial Energy Metabolism to Improve Sepsis-Associated Acute Kidney Injury: A Mechanistic Study

涉及领域

acute kidney injury

数据类型

Whole genome sequencing
Raw sequence reads

物种名称

描述信息

Sepsis-associated acute kidney injury (S-AKI) is one of the most common and life-threatening complications in critically ill patients and is closely associated with poor outcomes. However, there are currently no effective drugs to prevent or treat S-AKI. The applicant's previous research has found that thiamine is associated with improved outcomes in patients with ventilator-associated pneumonia and sepsis in the intensive care unit. Therefore, in response to the urgent need for pharmacological treatment of S-AKI in clinical practice, this project aims to combine real-world clinical research with bioinformatics, network pharmacology, and basic experiments to explore the specific targets and mechanisms of action of thiamine in the treatment of S-AKI, providing a new direction for treatment.

样品范围

Multiisolate

发布日期

2025-12-24

项目资金来源

机构	项目类型	授权项目ID	授权项目名称
Jinan University	Jinan University Central University Basic Science Research Fund (Natural Science) Young Scientist Program	No.21624318	This research was supported by The FundamentalResearch Funds for The Central Universities

提交者

zichun cheng (zichunchengczz@gmail.com)

提交单位

Jinan University

提交日期

2024-12-08

项目包含数据信息

资源名称	描述
BioSample (313) show	-
SAMC4467861	next generation sequencing of cerebrospinal fluid
SAMC4467860	next generation sequencing of cerebrospinal fluid
SAMC4467859	next generation sequencing of blood
SAMC4467858	next generation sequencing of blood
SAMC4467857	next generation sequencing of sputum
SAMC4467856	next generation sequencing of sputum
SAMC4467855	next generation sequencing of ascites
SAMC4467854	next generation sequencing of ascites
SAMC4467853	next generation sequencing of blood
SAMC4467852	next generation sequencing of blood
SAMC4467851	next generation sequencing of bronchoalveolar lavage
SAMC4467850	next generation sequencing of bronchoalveolar lavage
SAMC4467849	next generation sequencing of blood
SAMC4467848	next generation sequencing of sputum
SAMC4467847	next generation sequencing of sputum
SAMC4467846	next generation sequencing of blood
SAMC4467845	next generation sequencing of sputum
SAMC4467844	next generation sequencing of blood
SAMC4467843	next generation sequencing of sputum
SAMC4467842	next generation sequencing of sputum
SAMC4467841	next generation sequencing of blood
SAMC4467840	next generation sequencing of sputum
SAMC4467839	next generation sequencing of sputum
SAMC4467838	next generation sequencing of bronchoalveolar lavage
SAMC4467837	next generation sequencing of bronchoalveolar lavage
SAMC4467836	next generation sequencing of blood
SAMC4467835	next generation sequencing of blood
SAMC4467834	next generation sequencing of bronchoalveolar lavage
SAMC4467833	next generation sequencing of bronchoalveolar lavage
SAMC4467832	next generation sequencing of blood
SAMC4467831	next generation sequencing of blood
SAMC4467830	next generation sequencing of blood
SAMC4467829	next generation sequencing of bronchoalveolar lavage
SAMC4467828	next generation sequencing of bronchoalveolar lavage
SAMC4467827	next generation sequencing of blood
SAMC4467826	next generation sequencing of blood
SAMC4467825	next generation sequencing of blood
SAMC4467824	next generation sequencing of blood
SAMC4467823	next generation sequencing of blood
SAMC4467822	next generation sequencing of sputum
SAMC4467821	next generation sequencing of sputum
SAMC4467820	next generation sequencing of blood
SAMC4467819	next generation sequencing of bronchoalveolar lavage
SAMC4467818	next generation sequencing of bronchoalveolar lavage
SAMC4467817	next generation sequencing of sputum
SAMC4467816	next generation sequencing of sputum
SAMC4467815	next generation sequencing of blood
SAMC4467814	next generation sequencing of blood
SAMC4467813	next generation sequencing of blood
SAMC4467812	next generation sequencing of cerebrospinal fluid
SAMC4467811	next generation sequencing of cerebrospinal fluid
SAMC4467810	next generation sequencing of bronchoalveolar lavage
SAMC4467809	next generation sequencing of bronchoalveolar lavage
SAMC4467808	next generation sequencing of blood
SAMC4467807	next generation sequencing of blood
SAMC4467806	next generation sequencing of cerebrospinal fluid
SAMC4467805	next generation sequencing of cerebrospinal fluid
SAMC4467804	next generation sequencing of cerebrospinal fluid
SAMC4467803	next generation sequencing of bronchoalveolar lavage
SAMC4467802	next generation sequencing of bronchoalveolar lavage
SAMC4467801	next generation sequencing of pleural effusion
SAMC4467800	next generation sequencing of pleural effusion
SAMC4467799	next generation sequencing of bronchoalveolar lavage
SAMC4467798	next generation sequencing of bronchoalveolar lavage
SAMC4467797	next generation sequencing of blood
SAMC4467796	next generation sequencing of blood
SAMC4467795	next generation sequencing of urine
SAMC4467794	next generation sequencing of urine
SAMC4467793	next generation sequencing of pleural effusion
SAMC4467792	next generation sequencing of sputum
SAMC4467791	next generation sequencing of sputum
SAMC4467790	next generation sequencing of blood
SAMC4467789	next generation sequencing of cerebrospinal fluid
SAMC4467788	next generation sequencing of cerebrospinal fluid
SAMC4467787	next generation sequencing of blood
SAMC4467786	next generation sequencing of blood
SAMC4467785	next generation sequencing of bronchoalveolar lavage
SAMC4467784	next generation sequencing of bronchoalveolar lavage
SAMC4467783	next generation sequencing of blood
SAMC4467782	next generation sequencing of blood
SAMC4467781	next generation sequencing of Blisters effusion
SAMC4467780	next generation sequencing of Blisters effusion
SAMC4467779	next generation sequencing of urine
SAMC4467778	next generation sequencing of urine
SAMC4467777	next generation sequencing of blood
SAMC4467776	next generation sequencing of bronchoalveolar lavage
SAMC4467775	next generation sequencing of bronchoalveolar lavage
SAMC4467774	next generation sequencing of blood
SAMC4467773	next generation sequencing of blood
SAMC4467772	next generation sequencing of cerebrospinal fluid
SAMC4467771	next generation sequencing of cerebrospinal fluid
SAMC4467770	next generation sequencing of sputum
SAMC4467769	next generation sequencing of sputum
SAMC4467768	next generation sequencing of blood
SAMC4467767	next generation sequencing of blood
SAMC4467766	next generation sequencing of blood
SAMC4467765	next generation sequencing of bronchoalveolar lavage
SAMC4467764	next generation sequencing of bronchoalveolar lavage
SAMC4467763	next generation sequencing of blood
SAMC4467762	next generation sequencing of bronchoalveolar lavage
SAMC4467761	next generation sequencing of bronchoalveolar lavage
SAMC4467760	next generation sequencing of blood
SAMC4467759	next generation sequencing of blood
SAMC4467758	next generation sequencing of bronchoalveolar lavage
SAMC4467757	next generation sequencing of bronchoalveolar lavage
SAMC4467756	next generation sequencing of blood
SAMC4467755	next generation sequencing of bronchoalveolar lavage
SAMC4467754	next generation sequencing of bronchoalveolar lavage
SAMC4467753	next generation sequencing of sputum
SAMC4467752	next generation sequencing of blood
SAMC4467751	next generation sequencing of blood
SAMC4467750	next generation sequencing of sputum
SAMC4467749	next generation sequencing of sputum
SAMC4467748	next generation sequencing of blood
SAMC4467747	next generation sequencing of blood
SAMC4467746	next generation sequencing of blood
SAMC4467745	next generation sequencing of bronchoalveolar lavage
SAMC4467744	next generation sequencing of bronchoalveolar lavage
SAMC4467743	next generation sequencing of sputum
SAMC4467742	next generation sequencing of sputum
SAMC4467741	next generation sequencing of blood
SAMC4467740	next generation sequencing of sputum
SAMC4467739	next generation sequencing of sputum
SAMC4467738	next generation sequencing of sputum
SAMC4467737	next generation sequencing of sputum
SAMC4467736	next generation sequencing of blood
SAMC4467735	next generation sequencing of bronchoalveolar lavage
SAMC4467734	next generation sequencing of bronchoalveolar lavage
SAMC4467733	next generation sequencing of blood
SAMC4467732	next generation sequencing of blood
SAMC4467731	next generation sequencing of sputum
SAMC4467730	next generation sequencing of sputum
SAMC4467729	next generation sequencing of blood
SAMC4467728	next generation sequencing of blood
SAMC4467727	next generation sequencing of blood
SAMC4467726	next generation sequencing of bronchoalveolar lavage
SAMC4467725	next generation sequencing of bronchoalveolar lavage
SAMC4467724	next generation sequencing of blood
SAMC4467723	next generation sequencing of bronchoalveolar lavage
SAMC4467722	next generation sequencing of bronchoalveolar lavage
SAMC4467721	next generation sequencing of blood
SAMC4467720	next generation sequencing of bronchoalveolar lavage
SAMC4467719	next generation sequencing of bronchoalveolar lavage
SAMC4467718	next generation sequencing of blood
SAMC4467717	next generation sequencing of bronchoalveolar lavage
SAMC4467716	next generation sequencing of bronchoalveolar lavage
SAMC4467715	next generation sequencing of blood
SAMC4467714	next generation sequencing of blood
SAMC4467713	next generation sequencing of bronchoalveolar lavage
SAMC4467712	next generation sequencing of bronchoalveolar lavage
SAMC4467711	next generation sequencing of blood
SAMC4467710	next generation sequencing of bronchoalveolar lavage
SAMC4467709	next generation sequencing of bronchoalveolar lavage
SAMC4467708	next generation sequencing of bronchoalveolar lavage
SAMC4467707	next generation sequencing of bronchoalveolar lavage
SAMC4467706	next generation sequencing of blood
SAMC4467705	next generation sequencing of blood
SAMC4467704	next generation sequencing of urine
SAMC4467703	next generation sequencing of bronchoalveolar lavage
SAMC4467702	next generation sequencing of bronchoalveolar lavage
SAMC4467701	next generation sequencing of bronchoalveolar lavage
SAMC4467700	next generation sequencing of blood
SAMC4467699	next generation sequencing of bronchoalveolar lavage
SAMC4467698	next generation sequencing of bronchoalveolar lavage
SAMC4467697	next generation sequencing of blood
SAMC4467696	next generation sequencing of blood
SAMC4467695	next generation sequencing of blood
SAMC4467694	next generation sequencing of bronchoalveolar lavage
SAMC4467693	next generation sequencing of bronchoalveolar lavage
SAMC4467692	next generation sequencing of sputum
SAMC4467691	next generation sequencing of sputum
SAMC4467690	next generation sequencing of blood
SAMC4467689	next generation sequencing of blood
SAMC4467688	next generation sequencing of pleural effusion
SAMC4467687	next generation sequencing of pleural effusion
SAMC4467686	next generation sequencing of bronchoalveolar lavage
SAMC4467685	next generation sequencing of bronchoalveolar lavage
SAMC4467684	next generation sequencing of blood
SAMC4467683	next generation sequencing of blood
SAMC4467682	next generation sequencing of blood
SAMC4467681	next generation sequencing of sputum
SAMC4467680	next generation sequencing of sputum
SAMC4467679	next generation sequencing of blood
SAMC4467678	next generation sequencing of blood
SAMC4467677	next generation sequencing of pleural effusion
SAMC4467676	next generation sequencing of pleural effusion
SAMC4467675	next generation sequencing of sputum
SAMC4467674	next generation sequencing of sputum
SAMC4467673	next generation sequencing of blood
SAMC4467672	next generation sequencing of blood
SAMC4467671	next generation sequencing of urine
SAMC4467670	next generation sequencing of urine
SAMC4467669	next generation sequencing of bronchoalveolar lavage
SAMC4467668	next generation sequencing of bronchoalveolar lavage
SAMC4467667	next generation sequencing of sputum
SAMC4467666	next generation sequencing of sputum
SAMC4467665	next generation sequencing of blood
SAMC4467664	next generation sequencing of blood
SAMC4467663	next generation sequencing of hydropericardium
SAMC4467662	next generation sequencing of blood
SAMC4467661	next generation sequencing of blood
SAMC4467660	next generation sequencing of bronchoalveolar lavage
SAMC4467659	next generation sequencing of bronchoalveolar lavage
SAMC4467658	next generation sequencing of blood
SAMC4467657	next generation sequencing of pleural effusion
SAMC4467656	next generation sequencing of sputum
SAMC4467655	next generation sequencing of sputum
SAMC4467654	next generation sequencing of cerebrospinal fluid
SAMC4467653	next generation sequencing of cerebrospinal fluid
SAMC4467652	next generation sequencing of blood
SAMC4467651	next generation sequencing of blood
SAMC4467650	next generation sequencing of sputum
SAMC4467649	next generation sequencing of sputum
SAMC4467648	next generation sequencing of cerebrospinal fluid
SAMC4467647	next generation sequencing of cerebrospinal fluid
SAMC4467646	next generation sequencing of bronchoalveolar lavage
SAMC4467645	next generation sequencing of bronchoalveolar lavage
SAMC4467644	next generation sequencing of blood
SAMC4467643	next generation sequencing of blood
SAMC4467642	next generation sequencing of bronchoalveolar lavage
SAMC4467641	next generation sequencing of bronchoalveolar lavage
SAMC4467640	next generation sequencing of blood
SAMC4467639	next generation sequencing of blood
SAMC4467638	next generation sequencing of blood
SAMC4467637	next generation sequencing of blood
SAMC4467636	next generation sequencing of blood
SAMC4467635	next generation sequencing of blood
SAMC4467634	next generation sequencing of sputum
SAMC4467633	next generation sequencing of sputum
SAMC4467632	next generation sequencing of cerebrospinal fluid
SAMC4467631	next generation sequencing of cerebrospinal fluid
SAMC4467630	next generation sequencing of blood
SAMC4467629	next generation sequencing of blood
SAMC4467628	next generation sequencing of blood
SAMC4467627	next generation sequencing of blood
SAMC4467626	next generation sequencing of bronchoalveolar lavage
SAMC4467625	next generation sequencing of bronchoalveolar lavage
SAMC4467624	next generation sequencing of ascites
SAMC4467623	next generation sequencing of ascites
SAMC4467622	next generation sequencing of blood
SAMC4467621	next generation sequencing of blood
SAMC4467620	next generation sequencing of bronchoalveolar lavage
SAMC4467619	next generation sequencing of bronchoalveolar lavage
SAMC4467618	next generation sequencing of bronchoalveolar lavage
SAMC4467617	next generation sequencing of bronchoalveolar lavage
SAMC4467616	next generation sequencing of cerebrospinal fluid
SAMC4467615	next generation sequencing of cerebrospinal fluid
SAMC4467614	next generation sequencing of bronchoalveolar lavage
SAMC4467613	next generation sequencing of bronchoalveolar lavage
SAMC4467612	next generation sequencing of blood
SAMC4467611	next generation sequencing of blood
SAMC4467610	next generation sequencing of blood
SAMC4467609	next generation sequencing of blood
SAMC4467608	next generation sequencing of bronchoalveolar lavage
SAMC4467607	next generation sequencing of bronchoalveolar lavage
SAMC4467606	next generation sequencing of bronchoalveolar lavage
SAMC4467605	next generation sequencing of bronchoalveolar lavage
SAMC4467604	next generation sequencing of blood
SAMC4467603	next generation sequencing of blood
SAMC4467602	next generation sequencing of blood
SAMC4467601	next generation sequencing of blood
SAMC4467600	next generation sequencing of blood
SAMC4467599	next generation sequencing of blood
SAMC4467598	next generation sequencing of bronchoalveolar lavage
SAMC4467597	next generation sequencing of bronchoalveolar lavage
SAMC4467596	next generation sequencing of bronchoalveolar lavage
SAMC4467595	next generation sequencing of bronchoalveolar lavage
SAMC4467594	next generation sequencing of ascites
SAMC4467593	next generation sequencing of ascites
SAMC4467592	next generation sequencing of blood
SAMC4467591	next generation sequencing of blood
SAMC4467590	next generation sequencing of blood
SAMC4467589	next generation sequencing of blood
SAMC4467588	next generation sequencing of blood
SAMC4467587	next generation sequencing of blood
SAMC4467586	next generation sequencing of bronchoalveolar lavage
SAMC4467585	next generation sequencing of bronchoalveolar lavage
SAMC4467584	next generation sequencing of blood
SAMC4467583	next generation sequencing of blood
SAMC4467582	next generation sequencing of bronchoalveolar lavage
SAMC4467581	next generation sequencing of bronchoalveolar lavage
SAMC4467580	next generation sequencing of blood
SAMC4467579	next generation sequencing of blood
SAMC4467578	next generation sequencing of cerebrospinal fluid
SAMC4467577	next generation sequencing of cerebrospinal fluid
SAMC4467576	next generation sequencing of cerebrospinal fluid
SAMC4467575	next generation sequencing of cerebrospinal fluid
SAMC4467574	next generation sequencing of blood
SAMC4467573	next generation sequencing of blood
SAMC4467572	next generation sequencing of blood
SAMC4467571	next generation sequencing of blood
SAMC4467570	next generation sequencing of bronchoalveolar lavage
SAMC4467569	next generation sequencing of bronchoalveolar lavage
SAMC4467568	next generation sequencing of blood
SAMC4467567	next generation sequencing of blood
SAMC4467566	next generation sequencing of bronchoalveolar lavage
SAMC4467565	next generation sequencing of bronchoalveolar lavage
SAMC4467564	next generation sequencing of blood
SAMC4467563	next generation sequencing of blood
SAMC4467562	next generation sequencing of bronchoalveolar lavage
SAMC4467561	next generation sequencing of bronchoalveolar lavage
SAMC4467560	next generation sequencing of blood
SAMC4467559	next generation sequencing of blood
SAMC4467558	next generation sequencing of bronchoalveolar lavage
SAMC4467557	next generation sequencing of bronchoalveolar lavage
SAMC4467556	next generation sequencing of ascites
SAMC4467555	next generation sequencing of ascites
SAMC4467554	next generation sequencing of blood
SAMC4467553	next generation sequencing of blood
SAMC4467552	next generation sequencing of sputum
SAMC4467551	next generation sequencing of sputum
SAMC4467550	next generation sequencing of blood
SAMC4467549	next generation sequencing of blood
GSA (1)	-
CRA021369	Thiamine-Mediated S100A9 Regulation of AKT/AMPK-Dependent Mitochondrial Energy Metabolism to Improve Sepsis-Associated Acute Kidney Injury: A Mechanistic Study