| 项目编号 |
PRJCA033506 |
| 项目标题 |
Mast cells boost anti-tumor potency of MAIT cells via inflammasome activation(scRNA-seq) |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
|
| 描述信息 |
The focus of our study is to provide an atlas of previously unappreciated mast cells in lung adenocarcinoma (LUAD) and comprehensively elucidate their infiltration patterns, heterogeneity, and mechanisms in the LUAD microenvironment. We utilized whole genome sequencing (WGS) and RNA sequencing (RNA-seq) on 1019 paired normal lung tissues and LUAD and enrolled the flow cytometry cohort and TMA cohort to study the dynamic patterns of mast cells during LUAD progression(from indolent to invasive LUAD) |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-05-09 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40603850
|
Mast cells boost anti-tumor potency of MAIT cells via inflammasome-dependent secretion of IL-18
|
Nature Communications
|
10.1038/s41467-025-61324-w
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of People's Republic of China
|
|
82430099
|
|
| National Natural Science Foundation of People's Republic of China
|
|
81930073
|
|
| National Natural Science Foundation of China (NSFC)
|
|
U23A6010
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82203504
|
|
| The Cooperation Project of Conquering Major Diseases in Xuhui District
|
|
XHLHGG202101
|
|
| The National Key R&D Program of China
|
|
2022YFA1103900
|
|
| The Strategic Priority Research Program of the Chinese Academy of Sciences
|
|
XDB0940102
|
|
|
|
| 提交者 |
Zhiwei
Cao (zwcao@fudan.edu.cn)
|
| 提交单位 |
Fudan University |
| 提交日期 |
2024-12-10 |
