| 项目编号 |
PRJCA033553 |
| 项目标题 |
Transcriptomics and epigenomics of E15.5 female germ cells |
| 涉及领域 |
Model organism |
| 数据类型 |
Epigenomics
Transcriptome or Gene expression
Raw sequence reads
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Epigenetic reprogramming is widespread and highly active during gametogenesis, which is usually involving in the expression of critical genes. The expression of genes couple with transcription activation, and the transcriptional regulation by transcription factors predetermines protein translation for biological processes. In this study, we found that EHMT1-mediated re-establishment played crucial roles in the progression of meiosis in female germ cells. EHMT1 deficient female mice were nearly infertile due to the arrest of zygotene in embryonic germ cells, which was caused by down-regulated expression of key meiotic genes. Furthermore, we identified transcription suppressor for meiotic genes by combining RNA-seq, Cut&Tag seq analysis of H3K9me2 and luciferase reporter assays. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-06-19 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40650982
|
Re-establishment of H3K9me2 eliminates the transcriptional inhibition of ST18 on meiotic genes and orchestrates female germ cell development
|
Nucleic Acids Research
|
10.1093/nar/gkaf657
|
2025
|
| 41014638
|
Re-establishment of H3K9me2 eliminates the transcriptional inhibition of ST18 on meiotic genes and orchestrates female germ cell development
|
Nucleic Acids Research
|
10.1093/nar/gkaf979
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82171646
|
|
| Beijing Natural Science Foundation
|
|
Z240020
|
|
| National R&D Program of China
|
|
2022YFA0806302
|
|
|
|
| 提交者 |
Yi Na
Zhang (zhangyina22@mails.ucas.ac.cn)
|
| 提交单位 |
Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology |
| 提交日期 |
2024-12-11 |
