| 项目编号 | PRJCA034043 | ||||||||
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| 项目标题 | A Single-Cell Transcriptomic Profiling Unveils the Geroprotective Role of GRHL2 in Primate Prostate Aging | ||||||||
| 涉及领域 | Medical | ||||||||
| 数据类型 | Transcriptome or Gene expression | ||||||||
| 物种名称 |
Mus musculus
Macaca fascicularis Homo sapiens |
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| 描述信息 | Prostate aging leads to benign prostatic hyperplasia or prostate cancer, whereas cellular and molecular mechanisms remain largely enigmatic, particularly in primates. Through a single-cell transcriptomic analysis of primate prostate aging, we have delineated the aging-associated molecular signatures, highlighting increased cellular senescence, fibrosis, and inflammation. We identified the downregulation of GRHL2, a key transcription factor, as a critical initiator of senescence in prostate epithelial cells. This downregulation represses CDK19 transcription, subsequently releasing P53 from the CDK19-P53 complex sequestration and activating P21 transcription, which are essential steps in the cellular senescence pathway. Furthermore, GRHL2-based gene therapy delays prostate epithelial cell senescence and mitigates the aging phenotypes in prostate in vivo. Overall, our findings enhance the current understanding of prostate aging in primates and provide a foundation for developing targeted therapeutic strategies for human prostate aging and its associated disorders. | ||||||||
| 样品范围 | Single cell | ||||||||
| 发布日期 | 2024-12-22 | ||||||||
| 项目资金来源 |
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| 提交者 | Guanghui Liu (ghliu@ioz.ac.cn) | ||||||||
| 提交单位 | Institute of Zoology, Chinese Academy of Sciences | ||||||||
| 提交日期 | 2024-12-22 |