项目编号 PRJCA034049
项目标题 Influenza virus dissemination and infection leads to tissue resident cell injury and dysfunction in viral sepsis
涉及领域 Medical
数据类型 Single cell sequencing
物种名称 Mus musculus
描述信息 Influenza A virus PR8 was intranasally administrated to establish the VS survival, VS lethal, and BS mouse models, respectively. We conducted single-cell transcriptome sequencing on the lungs at 1, 2, 3, 5, and 7 dpi for all these three groups.The lung tissues were harvested from three animals for each group on 1, 2, 3, 5, 7 dpi and control group and mixed for scSeq. Additional single lung tissues from VS survival group were obtained on 14 and 28 dpi. The liver tissues were harvested from three animals for VS and BS group on 3 and 7 dpi and control group and mixed for snSeq.
样品范围 Single cell
发布日期 2025-07-31
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
40983621 Ninjurin-1 mediates cell lysis and detrimental inflammation of PANoptosis during influenza A virus infection Signal Transduction and Targeted Therapy 10.1038/s41392-025-02391-9 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) Key Program 82241056
National Natural Science Foundation of China (NSFC) Young Scientists Fund 82100009
National Natural Science Foundation of China (NSFC) Special Funds 82030002
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2021-I2M-1-048
New Cornerstone Science Foundation none
提交者 Haibo Li (shrineswe@vip.qq.com)
提交单位 China-Japan Friendship Hospital
提交日期 2024-12-23

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