| 项目编号 |
PRJCA034467 |
| 项目标题 |
lncRNA IL6-AS1 promotes inflammatory effects in lung macrophages via exosomes through the S100A9/TLR4 pathway in COPD progression |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Musculus
Homo sapiens
|
| 描述信息 |
This study investigates the role of IL6-AS1, a highly expressed long non-coding RNA (lncRNA), in chronic obstructive pulmonary disease (COPD). An adeno-associated virus (AAV) was used to induce the expression of IL6-AS1 in mice, and they were exposed to cigarette smoke to establish a COPD model. Our findings indicate that the upregulation of IL6-AS1 in fibroblasts enhances the interaction between the S100A9 protein and the AGER and TLR4 receptors on lung macrophages, thereby exacerbating inflammatory responses. These findings suggest that IL6-AS1 may play a role in facilitating the crosstalk between fibroblasts and macrophages, leading to increased pulmonary inflammation. Mendelian randomization analysis further suggests a potential shared causal variant between IL6-AS1 and COPD. Taken together, this investigation provides valuable insights into the function of IL6-AS1 and its potential implications for the pathogenesis and therapeutic strategies in COPD. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-01-02 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40487749
|
Long Noncoding RNA Interleukin 6 Antisense RNA 1 Promotes Inflammatory Effects in Lung Macrophages via Exosomes Through the S100A9/TLR4 Pathway in Chronic Obstructive Pulmonary Disease Progression
|
MedComm
|
10.1002/mco2.70204
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82200045
|
|
|
|
| 提交者 |
Erkang
Yi (188648614@qq.com)
|
| 提交单位 |
Guangzhou Laboratory |
| 提交日期 |
2025-01-02 |
