| 项目编号 |
PRJCA035256 |
| 项目标题 |
Gut microbe-derived betulinic acid alleviates sepsis-induced acute liver injury |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
The male C57BL/6J mice were housed under conditions of ad libitum access to food and water. The induction of polymicrobial sepsis was achieved using the cecal ligation and puncture (CLP) method, as described previously . In brief, the mice were initially administered anesthesia before CLP treatment by ligating and puncturing their cecum twice using an 18 G needle. The survival rate was observed every hour during the first 48-hour period. For exercise training, mice were randomly assigned to two activity groups: exercise training (Exe) or sedentary control (Ctrl). The Exe mice underwent a treadmill exercise routine as described previously, starting at 5 meters (m) per minute for 10 minutes and then increasing to 15 m per minute for 60 minutes once daily for 14 days. |
| 样品范围 |
Monoisolate |
| 发布日期 |
2025-01-23 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 39887250
|
Gut microbe-derived betulinic acid alleviates sepsis-induced acute liver injury by inhibiting macrophage NLRP3 inflammasome in mice
|
mBio
|
10.1128/mbio.03020-24
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
Young Scientists Fund
|
82302480
|
|
|
|
| 提交者 |
Wei
Huang (wei11920012@163.com)
|
| 提交单位 |
Southern Medical University |
| 提交日期 |
2025-01-18 |
