| 项目编号 |
PRJCA035387 |
| 项目标题 |
Single-cell Transcriptome Analysis Reveals Mechanical Properties of Leukemic Stem Cells in AML. |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
|
| 描述信息 |
Leukemic stem cells (LSCs) are crucial drivers of leukemia, yet the mechanisms underlying their function remain poorly understood. Here, we investigated the physical properties of LSCs and their potential role in LSCs function. single-cell RNA-sequencing analysis has revealed that small-sized LSCs aberrantly overexpress ALDH1A1, a crucial regulator of stem cell function. Lastly, ALDH1A1 inhibition increases cell stiffness and suppresses leukaemogenesis in patient-derived xenograft models. Our findings establish a novel link between the biomechanics of LSCs and their function in leukemia, providing a compelling rationale for targeting therapy-resistant LSCs by inhibiting G3BP. Overall, our study provides valuable insights into the mechanisms of LSCs function and has significant implications for the development of more effective therapies for this devastating disease. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-01-23 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41326331
|
Targeting leukemic stem cell biomechanics suppresses stemness and enhances NK cell-mediated immunotherapy
|
Nature Communications
|
10.1038/s41467-025-65842-5
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Natural Science Foundation of China
|
|
82370159
|
|
|
|
| 提交者 |
fang
Ni (fangni@ustc.edu.cn)
|
| 提交单位 |
USTC |
| 提交日期 |
2025-01-21 |
