| 项目编号 |
PRJCA035453 |
| 项目标题 |
Single-cell transcriptome analysis reveals the dynamic populations of vascular cells in neointima formation by endothelial MVP knockout |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Neointimal hyperplasia (NIH) are the major causes of re-stenosis in coronary intervention and the interventional strategies for it remains unclear. MVP is the predominant component of cellular vaults and participates in diverse biological processes including multidrug resistance, nuclear pore assembly, signal transduction, and immune response. However, the exact role of endothelial MVP in neointimal hyperplasia remains unclear. This study was aimed at gaining new insights into the heterogeneity of vascular cells in neointimal hyperplasia caused by endothelial MVP deficiency using single-cell RNA sequencing. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-03-21 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40348769
|
Endothelial major vault protein alleviates vascular remodeling via promoting Parkin-mediated mitophagy
|
Nature Communications
|
10.1038/s41467-025-59644-y
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82100433
|
|
|
|
| 提交者 |
Bin
Jiang (jiangbin@njmu.edu.cn)
|
| 提交单位 |
Nanjing Medical University |
| 提交日期 |
2025-01-22 |
