| 项目编号 |
PRJCA035547 |
| 项目标题 |
Genome-wide STR variation of populations in Qinghai-Tibet Plateau and neighboring regions |
| 涉及领域 |
Evolution |
| 数据类型 |
Whole genome sequencing
Variation
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Short tandem repeats (STRs) have emerged as fundamental regulatory elements in mediating complex traits and adaptive evolution across species. Adapting to and thriving in highland environments represent a significant milestone in human evolutionary history, whereas the roles of STRs in regulating high-altitude adaptation (HAA) remain unknown. Despite the important biological significances, variation patterns of pSTRs among highland and lowland populations and their roles in mediating HAA phenotypes remained unknown. China harbors one of the largest populations globally that occupy regions ranging from Qinghai-Tibet Plateau to the lowland cores of East Asia. Among these, Tibeto-Burman (TB) speakers belong to an ethnolinguistically cohesive group. Nowadays, most TB-speaking populations reside in the Pan-Tibetan Highlands and neighboring regions in mainland China, where geographical barriers have profoundly influenced their genetic backgrounds and phenotypic traits since their divergence from Sinitic speakers, i.e., Han Chinese. The distinguished demographic history and evolutionary trajectory of these populations make them ideal objects for surveying genome-wide STR diversities to shade light on the genetic basis of local adaptation. In this study, we integrated 7,876 whole-genome sequencing samples, including 3,808 newly sequenced Tibeto-Burman (TB) speakers and Han Chinese in Qinghai-Tibet Plateau and neighboring regions, to interrogate the variation patterns and functions of over 1.1 million genome-wide STRs. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-09-11 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41105762
|
Short tandem repeats in populations of the Qinghai-Tibet Plateau and adjacent regions provide insights into high-altitude adaptation
|
Science Advances
|
10.1126/sciadv.adx1590
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
|
|
ZYJC20002
|
|
|
|
| 提交者 |
Yuguo
Huang (hugo_wonders@outlook.com)
|
| 提交单位 |
West China Hospital of Sichuan University |
| 提交日期 |
2025-01-24 |
