| 项目编号 |
PRJCA036442 |
| 项目标题 |
Noninvasive Prognostic Classification of ITH in HCC with Multi-Omics Insights and Therapeutic Implications |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
This project aims to develop a noninvasive prognostic classification tool for assessing intratumoral heterogeneity (ITH) in hepatocellular carcinoma (HCC) using MRI-based radiomics and multi-omics insights. By integrating radiomics with molecular data, we identified distinct radiological phenotypes of ITH that are strongly correlated with prognosis and biological characteristics. This method provides an accurate, noninvasive way to classify ITH, offering insights into underlying molecular mechanisms such as extracellular matrix remodeling. The approach promises broader applications in oncology, particularly in tailoring personalized treatment strategies for HCC and potentially other solid tumors. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-03-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40315307
|
Noninvasive prognostic classification of ITH in HCC with multi-omics insights and therapeutic implications
|
Science Advances
|
10.1126/sciadv.ads8323
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
N/A
|
|
|
|
| 提交者 |
Xiao
Liang (srrshlx@zju.edu.cn)
|
| 提交单位 |
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2025-02-21 |
