| 项目编号 |
PRJCA036661 |
| 项目标题 |
TRIM21 orchestrates AKT K27-linked ubiquitination to counteract cancer chemotherapeutic resistance |
| 涉及领域 |
Medical |
| 数据类型 |
Phenotype or Genotype
Raw sequence reads
Proteome
|
| 物种名称 |
Mus musculus
Homo sapiens
|
| 描述信息 |
Ubiquitin modifications play diverse and predominant roles in virous physiological and pathological processes. However, the impact of atypical ubiquitin modification on AKT and its potential role in tumorigenesis remain largely unclear. Although K48-linked ubiquitin-mediated degradation of phosphorylated AKT and K63-linked ubiquitin-mediated activation of AKT have been reported, whether and how AKT undergoes non-canonical types of ubiquitination in pathophysiological conditions have not been defined.Through systematic ubiquitin analyses, we have observed that AKT undergoes K27-linked ubiquitination to imply its negative regulation conditions. |
| 样品范围 |
Multispecies |
| 发布日期 |
2025-02-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41188598
|
TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance
|
Nature Structural & Molecular Biology
|
10.1038/s41594-025-01697-0
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
32070767
|
|
| National Natural Science Foundation of China (NSFC)
|
|
32100559
|
|
| National Natural Science Foundation of China (NSFC)
|
|
82373307
|
|
| Guangdong Basic and Applied Basic Research Foundation
|
|
2023A1515010385
|
|
|
|
| 提交者 |
Jianping
Guo (guojp6@mail.sysu.edu.cn)
|
| 提交单位 |
The First Affiliated Hospital, Sun Yat-sen University |
| 提交日期 |
2025-02-26 |
