| 项目编号 |
PRJCA036895 |
| 项目标题 |
Evaluating the Clinical Utility of Next-Generation Sequencing Liquid Biopsy in Advanced NSCLC Patients: Insights from a Chinese Cohort |
| 涉及领域 |
Medical |
| 数据类型 |
Raw sequence reads
Genome sequencing
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
In this study, we explored the potential of cell-free circulating tumor DNA (ctDNA)-based next-generation sequencing (NGS) as a tool for personalizing treatment in Chinese patients with advanced non-small cell lung cancer (NSCLC). Despite the growing interest in ctDNA as a non-invasive alternative to tissue biopsy for mutational profiling, its clinical application remains underexplored in Chinese NSCLC populations. Through a retrospective analysis of NGS results from 522 Chinese patients diagnosed with stage III or IV NSCLC, we assessed the feasibility of using ctDNA-based NGS to detect mutations and guide targeted therapies. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-03-04 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41239261
|
Implementing liquid biopsy NGS in stage III/IV NSCLC: clinical utility assessment from a real-world Chinese cohort
|
BMC Cancer
|
10.1186/s12885-025-15227-0
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82072985
|
|
| the N10 Found project of Harbin Medical University Cancer Hospital
|
|
Nn102024-05
|
|
| Heilongjiang Province Innovation Base Award Project
|
|
JD2023SJ03
|
|
| Natural Science Foundation of Heilongjiang Province
|
|
LH2022H065
|
|
| Wu-Jieping Medical Foundation
|
|
320.6750.19089-22
|
|
| Wu-Jieping Medical Foundation
|
|
320.6750.19089-48
|
|
|
|
| 提交者 |
guangyu
shan (guangyushan@usci-ivd.cn)
|
| 提交单位 |
Beijing USCI Medical Devices Co., Ltd. |
| 提交日期 |
2025-03-04 |
