| 描述信息 |
Aging is a common physiological and molecular change process, accompanied by the decline and aging of organ functions, closely related to disease susceptibility, and ultimately leading to death. Aging can cause metabolic disorders in the human body, leading to the occurrence of a variety of diseases, such as neurodegenerative diseases, metabolic diseases, and cancer. Studies have shown that changes in telomeres and DNA methylation are related to age and can reflect physiological age and biological age. In addition to epigenetic markers, some clinical markers related to metabolic disorders and type 2 diabetes also change with age. Although a large number of aging studies based on model animals have been reported, the molecular changes that occur during human aging and the heterogeneity of the aging process at the individual level and in a short period of time have not yet been fully understood. This project intends to conduct in-depth longitudinal metabolomics analysis of the elderly population to study metabolic changes related to aging, comprehensively reveal the metabolic characteristics of aging, and screen aging markers. Considering that aging is related to a variety of chronic diseases, the differences in aging characteristics between elderly people with chronic diseases and those without chronic diseases will be compared to reveal the aging characteristics of different elderly groups and reflect the impact of personal lifestyle and disease history on aging. By analyzing the characteristics and types of molecular pathways that change longitudinally over time in specific individuals, different aging patterns (i.e., age types) will be defined, providing a molecular-level assessment method for individual aging and a scientific basis for aging monitoring and intervention. |
