| 项目编号 |
PRJCA037708 |
| 项目标题 |
Alterations in the gut microbiome are associated with increased blood ammonia and hepatic encephalopathy in patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
|
| 物种名称 |
human gut metagenome
|
| 描述信息 |
In this study, stool samples from 67 patients were collected preoperatively and one month postoperatively and metagenomic sequencing was performed to assess the composition of the gut microbiota. We demonstrated that Phocaeicola vulgatus increased after TIPS, along with a downregulation of the urea cycle. A positive correlation was observed between Phocaeicola vulgatus and elevated blood ammonia levels. Patients exhibiting increased blood ammonia after TIPS showed significant enrichment of Phocaeicola vulgatus, accompanied by a reduction in the urea cycle and associated enzymes. Similar microbiota alterations were identified in patients experiencing postoperative hepatic encephalopathy. In conclusion, the species Phocaeicola vulgatus may serve as a significant predictive microbe for hepatic encephalopathy after TIPS, which may be closely related to its function of ammonia metabolism. |
| 样品范围 |
Environment |
| 发布日期 |
2025-04-12 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40615853
|
Gut microbiome alterations and hepatic encephalopathy post-TIPS in liver cirrhosis patients
|
Journal of Translational Medicine
|
10.1186/s12967-025-06774-y
|
2025
|
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| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| No funding support
|
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|
|
|
| 提交者 |
Tang
Bo (botangxq@tmmu.edu.cn)
|
| 提交单位 |
Xinqiao Hospital, Third Military Medical University |
| 提交日期 |
2025-03-24 |
