| 项目编号 |
PRJCA037797 |
| 项目标题 |
Identification of altered immune landscape at single-cell resolution and its association with poor immune checkpoint inhibitor responses in NSCLC brain metastasis |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Brain metastasis, a common complication of advanced non-small cell lung cancer (NSCLC), leads to poor prognosis and reduces the efficacy of immune checkpoint inhibitors (ICIs). However, the mechanisms underlying this diminished ICI response remain unclear. Therefore, we comprehensively analyzed RNA sequencing data derived from 112,200 immune cells isolated from primary and brain metastatic NSCLC single-cell samples. |
| 样品范围 |
Single cell |
| 发布日期 |
2025-03-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 41807427
|
Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses
|
Nature Communications
|
10.1038/s41467-026-70715-6
|
2026
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
82473296
|
|
|
|
| 提交者 |
Tengfeifei
Teng (tengfeifei16@126.com)
|
| 提交单位 |
Shandong Cancer Hospital |
| 提交日期 |
2025-03-26 |
