| 项目编号 |
PRJCA038221 |
| 项目标题 |
RNA sequencing of drug-resistant liver cancer cell lines |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Using the human hepatocyte cell line Huh-7 Parental cell lines, we constructed lenvatinib-resistant strain (Huh-7 LR) and sorafenib-resistant strain (Huh-7 SR) through long-term stepwise drug induction. To explore the mechanisms of drug resistance, bulk RNA-seq was performed on the wild-type cells and the two drug-resistant cell lines. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-04-06 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40750772
|
Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma
|
Signal Transduction and Targeted Therapy
|
10.1038/s41392-025-02321-9
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82090051
|
|
|
|
| 提交者 |
Juan
Liu (liujuan1711@163.com)
|
| 提交单位 |
Beijing Tsinghua Chang Gung Hospital, Tsinghua University |
| 提交日期 |
2025-04-06 |
