| 项目编号 |
PRJCA038245 |
| 项目标题 |
Integrative Multi-Omics Analysis Reveals Microbiota Alterations and Clinical Indicators Predictive of Pulmonary Fibrosis Progression Following SARS-CoV-2 Infection |
| 涉及领域 |
Medical |
| 数据类型 |
Metagenome
|
| 物种名称 |
human sputum metagenome
human gut metagenome
|
| 描述信息 |
Pulmonary fibrosis following severe acute respiratory syndrome coronavirus 2 infection is a life-hreatening complication, characterized by irreversible respiratory dysfunction. Despite growing concerns about PF after SARS-CoV-2 infection, early recognition remains challenging. Additionally, the role of changes in respiratory and intestinal microbiota in PF progression remains insufficiently understood. This study employs a multi-omics approach to investigate alterations in both microbiota profiles and clinical indicators in patients with PF following SARS-CoV-2 infection.The aim is to develop a predictive model for the onset and progression of PF, incorporating risk stratification to enable early targeted therapeutic interventions and facilitate timely clinical decision-making, ultimately mitigating irreversible parenchymal remodeling and improving long-term respiratory outcomes. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-04-07 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82072377
|
|
|
|
| 提交者 |
Yifei
Shen (yifeishen@zju.edu.cn)
|
| 提交单位 |
The First Affiliated Hospital, Zhejiang University School of Medicine |
| 提交日期 |
2025-04-07 |
