| 项目编号 |
PRJCA039320 |
| 项目标题 |
Non-targeted Metabolomics of Fecal Samples in Hyperuricemic Mice. |
| 涉及领域 |
Medical |
| 数据类型 |
Metabonomics
|
| 物种名称 |
Mus
|
| 描述信息 |
To investigate the role and mechanisms of gut microbiota in hyperuricemia-induced renal injury, we established renal failure models using unilateral nephrectomized mice. After four weeks of adenine and potassium oxalate-supplemented diet, probiotic intervention was administered. Renal pathological and functional changes were assessed through H&E staining and plasma biochemical analysis. Gut microbiota composition and metabolite profiles were evaluated using 16S rRNA gene sequencing and non-targeted metabolomics of fecal samples. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-05-26 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 40335932
|
Compound probiotics alleviate hyperuricemia-induced renal injury via restoring gut microbiota and metabolism
|
BMC Microbiology
|
10.1186/s12866-025-04012-5
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Shanghai Municipal Science and Technology Commission Project
|
|
21dz1200204
|
|
|
|
| 提交者 |
Ping
Liu (531838567@qq.com)
|
| 提交单位 |
Fudan university Minhang Hospital |
| 提交日期 |
2025-04-24 |
