| 项目编号 |
PRJCA039715 |
| 项目标题 |
Radiological and pathological integration predicts the efficacy of bevacizumab with chemotherapy in colorectal cancer liver metastases |
| 涉及领域 |
Medical |
| 数据类型 |
Transcriptome or Gene expression
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
We focused on predicting the efficacy of bevacizumab plus chemotherapy unresectable colorectal cancer liver metastases with radiomics and pathomics, and explored the tumor microenvironment related to radiomic analysis based on the transcriptome sequencing of 14 matched samples obtained from before and after treatment. Our biological interpretation of the radiomic model correlated extracellular matrix remodeling and cancer-associated fibroblasts with poor bevacizumab efficacy. Pathological validation further identified fibroblasts and peritumoral angiogenesis as key resistance drivers. This integrative and comparative omics analysis proposed a new analytical template for uncovering the environmental heterogeneity and treatment resistance of colorectal cancer liver metastases, providing practical theoretical basis for the accurate stratification and translational perspectives for pre-treatment decision-making in the management of colorectal cancer liver metastases. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2025-12-03 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
|
|
Radiological and pathological integration predicts the efficacy of bevacizumab with chemotherapy in colorectal cancer liver metastases
|
Research Square
|
10.21203/rs.3.rs-7808212/v1
|
2025
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China
|
|
82173187
|
|
| the Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University
|
|
2022J005
|
|
|
|
| 提交者 |
Yuedan
Li (yuedan_li@163.com)
|
| 提交单位 |
Nanfang Hospital, Southern Medical University |
| 提交日期 |
2025-05-05 |
