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项目编号 PRJCA040009
项目标题 Co-condensation between transcription factor and chromatin remodeler selectively modulates gene expression
涉及领域 Medical
数据类型 Transcriptome or Gene expression
Raw sequence reads
物种名称 Homo sapiens
描述信息 Gene transcription is a fundamental process that plays critical roles in regulating cellular functionality and organismal development. The activation of gene transcription is a highly coordinated event that necessitates the orchestrated engagement of various transcription factors (TFs) and the transcription apparatus to access DNA at specific gene promoters and enhancers. The DNA accessibility, the most important prerequisite for the initiation of gene transcription, is produced by chromatin remodelers, which utilize ATP to reposition or evict nucleosomes from the DNA. Although it is well established that chromatin remodelers maintain an accessible chromatin environment, the mechanism how they are directed to specific genomic regions are not fully understood. Here we find that IDR-mediated selective co-condensation between TFs and chromatin remodeler represents a mechanism for specific gene activation.
样品范围 Monoisolate
发布日期 2025-11-14
出版信息
PubMed ID 文章标题 杂志名称 Doi 发表年份
41381493 Co-condensation between transcription factor and cBAF selectively modulates chromatin remodeling and gene expression Nature Communications 10.1038/s41467-025-67322-2 2025
项目资金来源
机构 项目类型 授权项目ID 授权项目名称
National Natural Science Foundation of China (NSFC) 32270745
National Natural Science Foundation of China (NSFC) 32270795
National Natural Science Foundation of China (NSFC) 32470791
The Natural Science Foundation of Shanghai 23ZR1466500
The Shanghai Municipal Health Commission 2022YQ067
提交者 Yi Lu (yilu_tju@tongji.edu.cn)
提交单位 Tongji University
提交日期 2025-05-11

项目包含数据信息

资源名称 描述
BioSample (316)  show -